prescribed to patients are as follows:

QR 678 ® Treatment for Hair Loss: The QR 678 ®is a proprietary, first in class hair fall & hair regrowth therapy, which has revolutionized the treatment of hair fall in alopecia. This formulation has been named QR678 inspired by the new generation ubiquitous presence of “Quick Response“ QR code. 678 in Morse Code signifies “there is no answer”. This formulation has been named QR678™ to signify a “Quick Response to a disease which earlier had no answer”.

The effects of the active ingredients of QR 678 ® on the scalp skin & on hair loss & hair regrowth are as follows:

S.No. 1    Sh-Polypeptide-9 (bio-mimicking VEGF)

Function:

• Sh-Polypeptide-9 is essential for angiogenesis and vascular permeability, may be responsible for maintaining proper vasculature around the hair follicle during the anagen growth phase. The highest expression of this peptide is found in Dermal papilla cells, and, is also expressed by follicular keratinocytes of the outer root sheath. This leads to reduced hair loss & significant hair regrowth. Existing follicles become thicker. And, dying hair follicles are invigorated and start growing again. Thus, there is an increase in number as well as thickness of hair follicles.
• It has been found to stimulate hair growth and increase hair size through facilitation of nutrient feeding to hair follicle by inducing angiogenesis (Ref. Kiichiro Y. et al., 2001, J. Clin. Invest. 107: 409–417).

S.No. 2    Sh-Polypeptide-1 (bio-mimicking bFGF)

• Sh-Polypeptide-1 has ability to stimulate neovascularization, is a potent in vitro mitogen for capillary endothelial cells, and stimulates angiogenesis in vivo
• This peptide may regulate the mitotic activity of epithelial-derived cells
• It is found in the Outer Root Sheath and in the region of the basal lamina of the follicle bulb, suggesting a role in bulb proliferation and fiber growth.
• It affects hair follicle initiation and development.
• This leads to reduced hair loss & significant hair regrowth. Existing follicles become thicker. And, dying hair follicles are invigorated and start growing again. Thus, there is an increase in number as well as thickness of hair follicles.

S.No. 3     Sh- Oligopeptide-2 (bio-mimicking IGF-1)

• Sh- Oligopeptide-2 appears to sustain normal anagen growth. They facilitate follicular proliferation, tissue remodeling, and the hair growth cycle, as well as follicular differentiation. IGF-1 mediated signaling is an important mitogenic and morphogenetic regulator in hair follicle biology.
• Androgen induction of follicular epithelial cell growth is mediated via this biomimetic peptide from dermal papilla cells.
• Strengthen hair while stimulating hair follicles to produce strong hair shaft.

S.No. 4    Sh-Polypeptide-3 (bio-mimicking KGF)

 Sh-Polypeptide-3  is secreted in large amounts by fibroblast-like stromal cells in epithelial tissues.

• Sh-Polypeptide-3 has been shown to regulate proliferation and differentiation in epithelial tissues and may regulate the clonogenic cells (stem cells) of the hair follicle.
• It increases hair follicle survival following cytotoxic insult.
• It stimulates capillary endothelial cell migration and proliferation and thus causes neovascularization.
• It helps strengthen hair while stimulating hair follicles to produce a strong hair shaft.

S.No. 5     Sh-Oligopeptide-4 (bio-mimicking Thymosin β4)

• Important mediator of cell migration and differentiation, it also promotes angiogenesis.
• Thymosin β4 accelerates hair growth, in part, due to its effect on critical events in the active phase of the hair follicle cycle, including promoting the migration of stem cells and their immediate progeny to the base of the follicle, differentiation, and extracellular matrix remodeling.
• Hepatocyte growth factor up-regulates thymosin β4 expression and may be acting by increasing thymosin β4 and/or synergizing with it.

  S.No. 6    Copper tripeptide-1

Delivery of copper peptide to the base of follicles helps strengthen hair while stimulating hair follicles to

produce strong hair shaft.

• Increase follicle size.
• Rebuilds the blood supply to damaged follicles, elevates the production of vascular endothelial growth factor.
• Increases melanin synthesis, necessary to keep hair from turning grey.
• Increases subcutaneous fat below the scalp which seems to support function for the hair follicle.
• Prolongs the hair growth phase.
• Inhibits 5-alpha reductase, the enzyme that reduces testosterone to DHT. DHT, in turn, is responsible for androgenetic alopecia. This inhibits the formation of DHT, hence reducing hair loss from male pattern balding in both men and women.
• Reduces inflammation.