A growth factors are a naturally sourced material capable of exciting cell development, growth and cell differentiation. Usually it is a necessary protein which is existing locally and causes development of that particular tissue. Growth factors are important for controlling a variety of cell procedures & act by executed to specific receptors on the surface of their target tissues.
The concept descends from a chance statement by my colleague Dr. Debraj Shome, during his analysis tests on rats models for treatment of a severe form of eye cancer called Retinoblastoma. This analysis was being performed together with the IIT Mumbai (2006), to create a new nano-molecule medication delivery system for Retinoblastoma. This medication delivery system is injected straight around the affected eye, so that the adverse reactions due to intravenous delivery of the medication could be prevented. A few times after the injections were given around the eyes of each mouse, my colleague Dr. Shome noticed that the hair around the mouse’s eye started vanishing due to regional contact with the medication. This led him to take a position that there must be some regional aspects which are important for development of hair and which were being affected by Carboplatin, since there was no other way Carboplatin could affect the development of hair, since the medication is not absorbed into one’s individual body afetr the hypodermic injection around the eye.
This was interesting as for decades, we believed that the inner state of wellness was the most important element for development of hair. This new postulate that development of hair could be affected by regional growth factors, despite the internal health being perfect, was amazing, revolutionary and new.
However, knowing that regional growth factors may cause development of hair is one thing, but showing the same and finding which ONE of the hundreds of regional necessary protein growth factors actually triggered development of hair or the lack of which triggered hair loss, was a challenging task! These phases, performed in joint cooperation with a few top Indian institutions took four decades of pain-staking analysis, & extended animal studies as well as individual tests.
The next step was to recognize by a procedure of medical analysis the most likely ones of the growth factors necessary protein existing in the scalp skin which could cause development. By a procedure of scientific exclusion, we recognized a total of five odd growth factors which could potentially be a factor in growth of hair.
It was not enough to merely recognize the elements though. We then ready these five growth factor molecules synthetically, outside the human body, by genetic engineering in the lab. These elements were then produced in five different arrangements and ratios, and it was decided to inject the solution into the scalp with the objective to deliver the molecules straight to the hair follicles, without having to cross the skin barrier. This entire procedure took one and a half decades.
A lead test was then performed with five volunteers in each of the five groups (n = 25), with early to average hair loss, being exposed to the injections. The outcomes were the best continually in one particular group of individual volunteers. This recently created compound thus seemed to be the most likely to cause growth of hair.