Composition of QR 678® hair growth formulation:
The effects of the active ingredients of QR678® on the scalp skin are as follows:
S.No. 1 Sh-Polypeptide-9 (bio-mimicking VEGF)
Sh-Polypeptide-9 is essential for angiogenesis and vascular permeability, may be responsible for maintaining proper vasculature around the hair follicle during the anagen growth phase. The highest expression of this peptide is found in Dermal papilla cells, and, is also expressed by follicular keratinocytes of the outer root sheath.
It has been found to stimulate hair growth and increase hair size through facilitation of nutrient feeding to hair follicle by inducing angiogenesis (Ref. Kiichiro Y. et al., 2001, J. Clin. Invest. 107: 409–417).
S.No. 2 Sh-Polypeptide-1 (bio-mimicking bFGF)
Sh-Polypeptide-1 has ability to stimulate neovascularization, is a potent in vitro mitogen for capillary endothelial cells, and stimulates angiogenesis in vivo
This peptide may regulate the mitotic activity of epithelial-derived cells
It is found in the Outer Root Sheath and in the region of the basal lamina of the follicle bulb, suggesting a role in bulb proliferation and fiber growth.
It affects hair follicle initiation and development.
S.No. 3 Sh- Oligopeptide-2 (bio-mimicking IGF-1)
Sh- Oligopeptide-2 appears to sustain normal anagen growth. They facilitate follicular proliferation, tissue remodeling, and the hair growth cycle, as well as follicular differentiation. IGF-1 mediated signaling is an important mitogenic and morphogenetic regulator in hair follicle biology.
Androgen induction of follicular epithelial cell growth is mediated via this biomimetic peptide from dermal papilla cells.
Strengthen hair while stimulating hair follicles to produce strong hair shaft.
S.No. 4 Sh-Polypeptide-3 (bio-mimicking KGF)
Sh-Polypeptide-3 has been shown to regulate proliferation and differentiation in epithelial tissues and may regulate the clonogenic cells (stem cells) of the hair follicle.
It increases hair follicle survival following cytotoxic insult.
It stimulates capillary endothelial cell migration and proliferation and thus causes neovascularization. (Journal of Cell Science 112, 2049-2057 (1999)).
It helps strengthen hair while stimulating hair follicles to produce strong hair shaft.
S.No. 5 Sh-Oligopeptide-4 (bio-mimicking Thymosin β4)
Important mediator of cell migration and differentiation, it also promotes angiogenesis.
Thymosin β4 accelerates hair growth, in part, due to its effect on critical events in the active phase of the hair follicle cycle, including promoting the migration of stem cells and their immediate progeny to the base of the follicle, differentiation, and extracellular matrix remodeling.
Hepatocyte growth factor up-regulates thymosin β4 expression and may be acting by increasing thymosin β4 and/or synergizing with it
S.No. 6 Copper tripeptide-1
Delivery of copper peptide to the base of follicles helps strengthen hair while stimulating hair follicles to
produce strong hair shaft.
Increase follicle size.
Rebuilds the blood supply to damaged follicles, elevates the production of vascular endothelial growth factor.
Increases melanin synthesis, necessary to keep hair from turning grey.
Increases subcutaneous fat below the scalp which seems to support function for the hair follicle.
Prolongs the hair growth phase.
Inhibits 5-alpha reductase, the enzyme that reduces testosterone to DHT. DHT, in turn, is responsible for androgenetic alopecia. (Ref. H Uno. et al. 1995. Journal of Invest. Dermatology. 101: 143-147) inhibit the forma tion of DHT, hence reducing hair loss from male pattern balding in both men and women.
S.No. 7 Ascorbic acid
Function: Vitamin C helps build collagen, which is highly important for hair growth, as well as maintaining the strength of hair. Vitamin C plays a necessary role in absorbing iron, which keeps the hair strands strong and healthy.
S.No. 8 Niacinamide
Function: Improves the scalp skin barrier function so that the hair follicles can develop properly.
S.No. 9 Retinol
Function: The follicle disintegrates during catagen in normal process. However, in case of alopecia, the hair follicle stem cell population remains, but the hair follicle dermal papilla detaches from the stem cells and prevents mesenchymal–epithelial interactions necessary for hair follicle cycling. This is particularly accentuated in Vitamin-A deficiency. Therefore Retinol administration is seen to help.
S.No. 10 Pantothenic acid
Function: Maintaining proper levels of pantothenic acid can strengthen hair follicles and their cells. This vitamin contributes to the nourishment of hair follicles, helping them to function properly and promote the growth of hair. Pantothenic acid can also help relieve the skin itching and flaking associated with dandruff and other similar disorders.
How does it work?
Intellectual Property & Timelines:
BACKED BY SCIENCE
The QR678 therapy arrests hair fall & increases the thickness, number and density of existing hair follicles leading to greater coverage in hair loss. The polypeptides used in the formulation are present in our scalp, making it natural growth factor-based treatment. The polypeptides penetrate deep into the scalp and provide nourishment to the scalp, which results in hair growth.
Unlike other treatments that contain minoxidil & finasteride, QR678 therapy is completely devoid of side effects. QR678 received FDA approval for manufacturing and sale by being the most effective therapy for hair regrowth.
HOW DOES IT WORK?