QR678® anti hair loss formulation: A cellular toxicity & animal efficacy study
Background and Scientific Context
Hair loss and hair thinning are complex biological phenomena influenced by a range of intrinsic and extrinsic factors. In clinical and academic literature, discussions around reasons for hair fall often encompass disruptions in hair follicle cycling, alterations in the scalp environment, systemic stressors, and exposure to medical treatments. Understanding these processes requires foundational research into hair biology, particularly the mechanisms that govern follicular growth, regression, and shedding. This preclinical animal study was undertaken to document biological observations associated with a proprietary formulation, QR678, within controlled laboratory settings as part of early-stage scientific inquiry.
Study Design and Experimental Framework
The investigation was structured as a preclinical study and included both in vitro and in vivo experimental components. Initial laboratory assessments focused on standardized cytotoxicity and cellular compatibility testing using human skin–derived cell lines. These experiments were designed to evaluate basic cell viability across predefined concentration ranges and to observe cellular responses under controlled exposure conditions. Such assessments are a routine part of formulation science and provide early insight into how complex formulations interact with skin-related cellular systems prior to animal-based evaluation.
Animal Models and Hair Cycle Evaluation
Following in vitro testing, the study progressed to in vivo experimentation using established rodent models commonly employed in dermatological research. These models are particularly valuable for studying hair cycle phases, as their follicular growth patterns are well characterized and allow structured observation across different stages of the hair cycle. One experimental arm focused on localized skin and follicular responses in mice following intradermal administration during specific phases of follicular activity. A second arm utilized a chemotherapy-induced alopecia model in rats to observe hair follicle structural characteristics under conditions associated with follicular stress and disruption.
Observational Parameters and Documentation
Observations throughout the study were documented descriptively using visual examination, standardized photographic recording, and histological analysis of skin and hair follicle architecture. In the murine model, localized changes in skin pigmentation were noted in areas corresponding to transitions within hair cycle phases, reflecting underlying follicular activity. In the chemotherapy-induced alopecia model, histological evaluation focused on follicular morphology, continuity of follicular structures, and the presence or absence of hair shafts within treated and untreated regions. These observations were recorded within predefined experimental parameters and without comparative or interventional endpoints.
Scope and Methodological Limitations
The study design did not involve systemic exposure, pharmacological comparators, or evaluation of cosmetic or clinical outcomes. No attempt was made to differentiate between hair shedding vs hair fall in a clinical sense, nor were patient-reported experiences or aesthetic changes assessed. Instead, the investigation remained focused on biological observation at the tissue and cellular level, consistent with the objectives of preclinical research.
Animal models play a specific and limited role in hair research. They allow controlled examination of hair follicle behavior and scalp-related biological responses that cannot be ethically or practically studied in humans at early stages. At the same time, such models do not replicate the full complexity of human hair loss, which may be influenced by lifestyle factors, hormonal variation, psychological stress, or long-term changes in hair care routine or scalp care routine. As such, findings from animal studies must be interpreted strictly within the boundaries of laboratory research methodology.
Research Relevance and Access to Full Study
This study contributes descriptive data to the broader scientific understanding of hair biology and follicular response under controlled experimental conditions. It provides an early research reference that may support further investigation within appropriately designed observational or clinical frameworks. The work does not address approaches described in consumer-facing discussions around hair loss solutions, anti hair loss solution strategies, or permanent hair loss solution concepts, which fall outside the scope of preclinical research.
Disclaimer:
The research papers and clinical articles referenced on this website are peer-reviewed scientific publications authored by qualified medical professionals and represent the observations and conclusions of the respective authors, based on their individual clinical research.
These clinical references are provided for informational and educational purposes and should not be interpreted as promotional claims or outcome guarantees by QR678®. Consumers are advised to consult a qualified healthcare professional for medical interpretation or hair- or scalp-related concerns.
QR678®: SCIENCE Backed Research & Development Proprietary Product Technology
The QR678® research & development platform technology is a proprietary first-in-class technology. This science backed technology is giving rise to multiple products that arrest hair fall and address the thickness, density of hair follicles leading to greater coverage in hair loss. This R&D technology deals with multiple human hair growth related growth factors that are naturally present in our scalp making products derived from these completely natural. Research on this platform technology has resulted in this being awarded USA & Indian patents and has led to over 16+ clinical research papers being published with products derived from this unique technology. The hair growth factors penetrate deep into the scalp and provide nourishment to the scale. Unlike other treatments that contains harmful medication, products derived from QR678® are almost completely devoid of side effects.
HOW DOES IT WORK?
Benefits of choosing QR678®
QR678® ADVANTAGES
(Derived From Plants)
Quick & Effective (Single
Session in 10 Minutes)
Non Surgical
Success Rate
13+ Published Researched Clinical Trials Demonstrating Efficacy
LIFE CHANGING RESULTS
PRE TREATMENT
POST 6 SESSIONS
PRE TREATMENT
POST 6 SESSIONS
PRE TREATMENT
POST 6 SESSIONS
25 year old female from alopecia areata, was also diagnosed with hypothyroid. She achieved impressive results with QR678, a completely steroid-off treatment.
PRE TREATMENT
POST 6 SESSIONS
39 year old male suffering from male pattern hair loss for 15 years gained a significant amount of hair with QR678
MEDIA INTERVIEWS
TESTIMONIALS
HIGHLIGHTS IN MEDICAL CONFERENCES
CUTICON – December 2023
Dazzling moments at Cuticon 2023, Gujarat! QR678 took centre stage, earning accolades from top medical professionals.
QR678 made it’s presence felt at FADS (Face Aesthetics Dermatologists Society), the 7th International Conference held at Goa. Renowned dermatologists got QR678 Neo administered and shared their positive experience.
QR678® drew attention with an enlightening session and live demonstration at CDCON 2022 – a platform to challenge changing practices along the lines of Exploration and Innovation.
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FAQ'S
How is QR678® better than other hair fall treatments?
QR678® is a mixture of natural growth factors that are already present in the scalp and therefore it is completely safe to use on everybody. It has the right concentration of specific hair growth factors and QR678® does not have any side effects, is performed as an outpatient procedure and the results are visible within eight weeks of starting the treatment. You can listen for yourself what the patients say about QR678® hair fall treatment https://www.youtube.com/watch?v=pIvjpQgSsrc
How often do I need to repeat QR678® treatment?
QR678® injections are administered in 8-12 sessions in about 3-4 weeks apart. The results are visible after few weeks. Once you have achieved the desired results the injections need not be repeated unless the hair fall starts again. This is because QR678® make the hair follicles healthy. Get to know more about why QR678® is highly effective in treating hair fall and increasing hair growth. http://www.qr678.in/
What precautions should I take after QR678® treatment?
QR678® is a completely safe treatment without side effects and you can go about your daily routine after the sessions. The only care you need to take is to use a gentle shampoo not before the next day of the treatment and avoid scratching and rubbing the treating area. If you have any other problem then consult your dermatologist. https://www.youtube.com/watch?v=LNm2z3EGLxg
Can QR678® be used after hair transplant?
Yes, using QR678® after hair transplant produces very successful results. QR678® gives faster density and reduces the catagen loss of transplanted hair. The growth factors in QR678® Neo help in faster healing and activate the dormant follicles and thus
- Increase the viability of hair follicles
- Improve healing and repairing of tissue process
- Strengthen the inactive hair follicles and stimulate hair growth
- Improves the health of existing hair and they will become fuller and stronger
QR678® can be given in multiple treatment sessions after three to four weeks after successful hair transplant surgery. QR678® can also be used before the hair transplant surgery to reduce the area of transplant and improve the results.
How is QR678® better than PRP and stem cell hair fall treatment?
QR678® is a relatively new treatment for hair fall and hair regrowth but in the short time of its invention QR678® has proven to be more effective than PRP and stem cell treatment for reducing hair fall. QR678® produces longer lasting and better results and is completely safe and without any side effects. QR678® can help treat and rogenetic alopecia, female pattern hair loss, and hair loss because of chemotherapy, seborrheic dermatitis, and alopecia areata.
PRP and stem cell on the other hand do not have the specific concentration of required growth factors, they lack standardisation in terms of treatment protocols and preparation of the solution injected and lack good quality studies to prove their benefits. produce guaranteed results and can cause tightness and tenderness in scalp,
scar tissue formation, calcification of the injected points, and formation of scar tissues. Both processes are still under investigation and their results are still awaiting confirmation. Dr Rinky Kapoor of The Esthetic Clinics explains the difference between QR678® and stem cell here: https://www.youtube.com/watch?v=wgNihm8ciu4 and
Can genetic hair loss be treated?
Yes genetic hair loss can be treated if the treatment is started in time. Heredity hair loss usually runs in the family and can affect both men and women. If you too have a close elder relative who lost his or hair in a patterned baldness then you should keep a close eye on your hair too. Hereditary hair loss usually happens in a pattern; M or W shaped in men and along the hair part in women. See the doctor immediately if you suffer from hair loss. There are many common and successful treatments available for genetic hair loss which include
- Topical and oral medications: These include Minoxidil topical lotion and Finasteride tablets.
- Hair transplantation using FUT and FUE methods.
- Nutritional supplements: Your physician might also suggest some hair supplements that can help arrest hair fall. Dietary supplements containing Vitamin A, C, and Biotin, zinc, and iron can also help control hair fall caused because of genetics.
Treatment option for Chemotherapy induced Alopecia?
Alopecia post chemotherapy is a very common consequence of cancer treatments and therapies and it is often the most psychologically and socially devastating side effect. Many patients shy away from the treatments because of fear of hair fall and hair loss. However, in most cases, such alopecia is reversible but the recovery takes several months and even up to a year. Some basic latest treatment methods will speed up the healing:
- Scalp Cooling: This is a FDA approved method for patients suffering from breast cancer. Scalp cooling or hypothermia results in constriction of the blood vessels in the scalp, which in turn leads to reduced delivery of chemotherapy to the hair. Scalp cooling devices consist of cooling unit that circulate the coolant on the scalp. This is done about 30 minutes before the start of chemotherapy. Patients can feel some mild discomfort, nausea, and dry skin because of scalp cooling.
- Topical Minoxidil: Minoxidil helps by increasing the blood flow to the hair follicle thereby preventing miniaturization of hair follicle.
- QR678® hair regrowth treatment: QR678® is a FDA approved, completely safe hair regrowth treatment that has no side effects or causes any discomfort to the patient. Clinical trials have proved QR678 to be effective in treatment of chemotherapy induced alopecia in both men and women. The results of QR678® last lifelong.