A COMPARATIVE DISSECTION: STEM CELL THERAPY VERUSUS QR678 NEO AS HAIR LOSS THERAPIES

Regenerative medicine is a major part of the rapidly emerging biomedical research over the last decade which mainly involves the development of new therapeutic strategies resulting in greater advancement in the field. Among the several therapeutic strategies available, the use of stem cell (SC) represents the mainstream technology to repair and rejuvenate the damaged tissue caused due to injury or chronic diseases.

Although in an attempt to better the current trends in hair loss therapy QR678 NEO is a relatively newer addition to the family and while both qr678- and SC-based therapies are destined to perform similar functions in restoring the damaged tissue to function normally, there exists a vast difference in their preparation procedures and their functionality.

SC is isolated from the adult tissues and cultured in sophisticated settings and requires several weeks to grow before they could be used for therapeutics. Contrary to SC, preparation of QR678 NEO is a hair growth factor regime, a bioengineered, recombinant formulation made up of a combination of growth factors, a plant-based polypeptide formulation that have been proved to be equivalent in the efficacy and safety.

STEM CELL THERAPY

Tissue-resident adult progenitor SCs have clinical importance due to their potential cell sources for transplantation in regenerative medicine and cancer therapies. The ability for indefinite self-renewal and multilineage differentiation into other types of cells represents SCs, which offers great promise in replacing the non-functional or lost cells to regenerate damaged or diseased tissues. The use of small subpopulation of adult stem or progenitor cells from tissues or organs from the same individual provides the possibility of stimulating those in vivo differentiation or cell replacement and gene therapies with multiple applications in humans without the risk of graft rejection. Research on tissue-resident SCs has explored the clinical interest in cell replacement-based therapies in regenerative medicine and cancer therapies.

Type and source of stem cells

Based on their origin, SCs are divided into two types – embryonic SCs (ESCs) and ASCs. ESCs are derived from epiblast of the blastocyst from which many tissues of embryo arise, whereas ASCs are localized in adult organs where these cells function to replace damaged cells during tissue regeneration. SCs are further classified into four types based on their trans-differentiation potential which include – totipotent, pluripotent, multipotent and unipotent SC.

How does stem cell therapy for hair work

Although the use of SC has immense medical benefits, their applications in many diseases are still in the research and clinical trial phase and further studies are required for its long-term use in clinical settings. Although SC has been practiced successfully in the treatment of hair loss there are certain concerns in using SC for therapies. SC propensity toward self-renewal and differentiation is highly influenced by their local environment making it difficult to interpret how a population of culture expands MSC may behave in vivo. Isolation and characterization of SC are crucial and even the isolated SC may have low survival rates. Culturing of SC without contamination requires highly experienced personnel and sophisticated laboratory settings.

 

Shortcomings of the stem cell therapy

Although the use of SC has immense medical benefits, their applications in many diseases are still in the research and clinical trial phase and further studies are required for its long-term use in clinical settings. Although SC has been practiced successfully in the treatment of hair loss there are certain concerns in using SC for therapies. SC propensity toward self-renewal and differentiation is highly influenced by their local environment making it difficult to interpret how a population of culture expands MSC may behave in vivo. Isolation and characterization of SC are crucial and even the isolated SC may have low survival rates. Culturing of SC without contamination requires highly experienced personnel and sophisticated laboratory settings.

The chances of microbial contamination of SC might result in complications, especially in those patients whose immune system is compromised. Careful monitoring and observation of this cell-based therapy are of paramount importance, since evidence has shown that adipose-derived MSCs have lost genetic stability over time and were prone to tumor formation. Based on the specific application, SC should be differentiated into appropriate cell types before they can be clinically used, failure of which may have deleterious effects. Furthermore, SC-based therapies require regular follow-up to monitor regenerated tissue over a period of complete recovery of a patient. In vivo niches, SCs are present under hypoxic conditions and change in oxygen levels can induce oxidative stress, which can influence SC phenotype, proliferation, fate, pluripotency, etc., Therefore, in vitro culture conditions used to study MSCs should be maintained similar to their in vivo niches.

QR678 NEO®

QR678 Neo® formula is a plant-based polypeptide formulation that biologically reproduces the function of QR678® and they have been proved to be equivalent in the efficacy and safety. QR678 Neo® contains a unique concentration of Sh-Polypeptide-9 (bio-mimicking Vascular endothelial growth factor -VEGF), Sh-Polypeptide-1 (bio-mimicking Fibroblast growth factor-bFGF), Sh- Oligopeptide-2 (bio-mimicking Insulin like growth factor–IGF 1), Sh-Polypeptide-3 (bio-mimicking Keratinocyte growth factor-KGF), copper tripeptide, and ShOligopeptide-4 (bio-mimicking Thymosin β4) dissolved in a sterile solution.

QR678 Neo® has been shown to be successful as a hair regrowth therapy in male and female pattern hair loss, in female patients with alopecia in PCOS in terms of lessening hair loss and new hair growth considerably. Also in chemotherapy related alopecia, QR678 Neo® has proved its effectiveness in both men and women with record of lung and breast cancer. It has also shown remarkable effectiveness in combination with Minoxidil and Finasteride.

The literature also suggests its beneficial effects and longevity of hair greater than PRP. QR678 Neo® has proved to have a significant effect on new hair growth as it contains several growth factors that have been shown to have an anti-inflammatory effect with no side effects even over longer period. Polypeptide growth factors play an imperative role in restoring tissue injury, controlling cell replication, development and differentiation, enhancing wound healing, and tissue regeneration. VEGF induces both vasculogenesis and angiogenesis following cellular damage. It has an immense impact on the permeability of blood vessels and is a potent angiogenic protein in a range of pathological neo-vascularization process.

IGF-I and KGF cDNA gene transfer separately helps in the advancement of dermal and epidermal transformation. FGF was also found to be an important factor in healing. Also, vitamins present in QR678 Neo® have been verified to have anti- inflammatory property. Since all previously mentioned therapies have limited results with adverse effects on long-term follow-up and considerably high relapse rate, QR678 Neo® proves to be the most effective method devoid of any significant adverse effects.

CONCLUSION

Since the QR678®

NATURAL INGREDIENTS
BACKED BY SCIENCE

The QR678 therapy arrests hair fall & increases the thickness, number and density of existing hair follicles leading to greater coverage in hair loss. The polypeptides used in the formulation are present in our scalp, making it natural growth factor-based treatment. The polypeptides penetrate deep into the scalp and provide nourishment to the scalp, which results in hair growth.

Unlike other treatments that contain minoxidil & finasteride, QR678 therapy is completely devoid of side effects. QR678 received FDA approval for manufacturing and sale by being the most effective therapy for hair regrowth.

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