Evaluation of efficacy of intradermal injection therapy vs derma roller application for administration of QR678® anti-hair loss formulation for the treatment of Androgenetic Alopecia—A prospective study
Background and Scientific Context
Hair thinning and hair loss are commonly associated with alterations in hair follicle activity, changes in the scalp environment, and disruptions in normal hair cycle phases. In scientific literature, procedural approaches such as microneedling have been explored as methods to facilitate localized scalp interventions and to study skin–follicle interactions under controlled conditions. This research paper examines the application of a dermaroller as a procedural adjunct in hair and scalp research, focusing on observational parameters rather than therapeutic outcomes.
The study situates dermaroller-assisted application within the broader framework of hair biology and scalp-focused research. Rather than addressing consumer-facing approaches to hair care or hair loss management, the investigation aims to document procedural observations related to scalp integrity, follicular response, and tolerability when a dermaroller is used as part of a controlled application protocol.
Study Design and Methodological Framework
The study was conducted as a clinical observational investigation involving adults with hair thinning and diffuse hair loss patterns. Participants were evaluated using predefined inclusion criteria and underwent dermaroller-assisted scalp application under standardized procedural conditions. The dermaroller was utilized to create uniform microchannels on the scalp surface, followed by localized application of a proprietary formulation, QR678, as part of the study protocol.
The procedural parameters, including needle length, application technique, and session intervals, were standardized to ensure consistency across participants. The study design did not include systemic exposure, pharmacological comparators, or placebo-controlled arms. All observations were recorded within the defined scope of the protocol and focused on documenting scalp and follicular parameters over the observation period.
Procedural Rationale and Scalp-Level Observation
Dermaroller-assisted application has been studied in dermatological research as a method to temporarily modulate the scalp environment and facilitate localized exposure at the skin surface. In this investigation, the dermaroller was employed to observe how controlled micro-injury influences scalp tolerance and follicular surroundings when combined with localized formulation application.
Observational focus areas included scalp appearance, immediate procedural responses, and changes noted during follow-up visits. The study did not attempt to differentiate clinical conditions or to categorize outcomes under consumer-oriented distinctions such as hair shedding vs hair fall. Instead, the emphasis remained on documenting observable scalp-level responses within the defined research setting.
Assessment Parameters and Documentation
Participants underwent standardized assessments at baseline and during follow-up visits. These assessments included clinical scalp examination, photographic documentation, and qualitative evaluation of hair density patterns. Observations were recorded descriptively, without comparative claims or statistical inference beyond the predefined scope of the study.
Attention was given to identifying any visible changes in follicular distribution, scalp texture, or hair shaft presence across the observation timeline. These findings were documented as part of an exploratory evaluation and were not positioned as indicators of clinical efficacy or cosmetic benefit.
Tolerability and Safety Observations
Procedural tolerability was documented throughout the study duration. Observed responses were primarily limited to transient, localized sensations commonly associated with dermaroller use, such as mild discomfort, erythema, or temporary scalp sensitivity. These observations resolved without intervention within the expected post-procedural timeframe.
No systemic adverse events were reported, and no escalation in hair shedding was documented during follow-up assessments. Safety observations were recorded descriptively and within the limitations of the observational study design.
Scope, Limitations, and Research Relevance
The study did not evaluate long-term outcomes, comparative procedural efficacy, or disease-specific hair loss conditions. It does not address reasons for hair thinning at an individual level, nor does it establish protocols for routine hair care or scalp care routine adoption. As with all observational studies, the findings are limited by sample size, study duration, and the absence of control groups.
Within these constraints, the research contributes to ongoing scientific discussion around procedural methods used in hair and scalp research and their role within formulation science. The observations serve as an exploratory reference for further structured investigation rather than a basis for clinical or consumer guidance.
Disclaimer:
The research papers and clinical articles referenced on this website are peer-reviewed scientific publications authored by qualified medical professionals and represent the observations and conclusions of the respective authors, based on their individual clinical research.
These clinical references are provided for informational and educational purposes and should not be interpreted as promotional claims or outcome guarantees by QR678®. Consumers are advised to consult a qualified healthcare professional for medical interpretation or hair- or scalp-related concerns.
QR678®: SCIENCE Backed Research & Development Proprietary Product Technology
The QR678® research & development platform technology is a proprietary first-in-class technology. This science backed technology is giving rise to multiple products that arrest hair fall and address the thickness, density of hair follicles leading to greater coverage in hair loss. This R&D technology deals with multiple human hair growth related growth factors that are naturally present in our scalp making products derived from these completely natural. Research on this platform technology has resulted in this being awarded USA & Indian patents and has led to over 16+ clinical research papers being published with products derived from this unique technology. The hair growth factors penetrate deep into the scalp and provide nourishment to the scale. Unlike other treatments that contains harmful medication, products derived from QR678® are almost completely devoid of side effects.
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Benefits of choosing QR678®
QR678® ADVANTAGES
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Session in 10 Minutes)
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13+ Published Researched Clinical Trials Demonstrating Efficacy
LIFE CHANGING RESULTS
PRE TREATMENT
POST 6 SESSIONS
PRE TREATMENT
POST 6 SESSIONS
PRE TREATMENT
POST 6 SESSIONS
25 year old female from alopecia areata, was also diagnosed with hypothyroid. She achieved impressive results with QR678, a completely steroid-off treatment.
PRE TREATMENT
POST 6 SESSIONS
39 year old male suffering from male pattern hair loss for 15 years gained a significant amount of hair with QR678
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CUTICON – December 2023
Dazzling moments at Cuticon 2023, Gujarat! QR678 took centre stage, earning accolades from top medical professionals.
QR678 made it’s presence felt at FADS (Face Aesthetics Dermatologists Society), the 7th International Conference held at Goa. Renowned dermatologists got QR678 Neo administered and shared their positive experience.
QR678® drew attention with an enlightening session and live demonstration at CDCON 2022 – a platform to challenge changing practices along the lines of Exploration and Innovation.
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FAQ'S
How is QR678® better than other hair fall treatments?
QR678® is a mixture of natural growth factors that are already present in the scalp and therefore it is completely safe to use on everybody. It has the right concentration of specific hair growth factors and QR678® does not have any side effects, is performed as an outpatient procedure and the results are visible within eight weeks of starting the treatment. You can listen for yourself what the patients say about QR678® hair fall treatment https://www.youtube.com/watch?v=pIvjpQgSsrc
How often do I need to repeat QR678® treatment?
QR678® injections are administered in 8-12 sessions in about 3-4 weeks apart. The results are visible after few weeks. Once you have achieved the desired results the injections need not be repeated unless the hair fall starts again. This is because QR678® make the hair follicles healthy. Get to know more about why QR678® is highly effective in treating hair fall and increasing hair growth. http://www.qr678.in/
What precautions should I take after QR678® treatment?
QR678® is a completely safe treatment without side effects and you can go about your daily routine after the sessions. The only care you need to take is to use a gentle shampoo not before the next day of the treatment and avoid scratching and rubbing the treating area. If you have any other problem then consult your dermatologist. https://www.youtube.com/watch?v=LNm2z3EGLxg
Can QR678® be used after hair transplant?
Yes, using QR678® after hair transplant produces very successful results. QR678® gives faster density and reduces the catagen loss of transplanted hair. The growth factors in QR678® Neo help in faster healing and activate the dormant follicles and thus
- Increase the viability of hair follicles
- Improve healing and repairing of tissue process
- Strengthen the inactive hair follicles and stimulate hair growth
- Improves the health of existing hair and they will become fuller and stronger
QR678® can be given in multiple treatment sessions after three to four weeks after successful hair transplant surgery. QR678® can also be used before the hair transplant surgery to reduce the area of transplant and improve the results.
How is QR678® better than PRP and stem cell hair fall treatment?
QR678® is a relatively new treatment for hair fall and hair regrowth but in the short time of its invention QR678® has proven to be more effective than PRP and stem cell treatment for reducing hair fall. QR678® produces longer lasting and better results and is completely safe and without any side effects. QR678® can help treat and rogenetic alopecia, female pattern hair loss, and hair loss because of chemotherapy, seborrheic dermatitis, and alopecia areata.
PRP and stem cell on the other hand do not have the specific concentration of required growth factors, they lack standardisation in terms of treatment protocols and preparation of the solution injected and lack good quality studies to prove their benefits. produce guaranteed results and can cause tightness and tenderness in scalp,
scar tissue formation, calcification of the injected points, and formation of scar tissues. Both processes are still under investigation and their results are still awaiting confirmation. Dr Rinky Kapoor of The Esthetic Clinics explains the difference between QR678® and stem cell here: https://www.youtube.com/watch?v=wgNihm8ciu4 and
Can genetic hair loss be treated?
Yes genetic hair loss can be treated if the treatment is started in time. Heredity hair loss usually runs in the family and can affect both men and women. If you too have a close elder relative who lost his or hair in a patterned baldness then you should keep a close eye on your hair too. Hereditary hair loss usually happens in a pattern; M or W shaped in men and along the hair part in women. See the doctor immediately if you suffer from hair loss. There are many common and successful treatments available for genetic hair loss which include
- Topical and oral medications: These include Minoxidil topical lotion and Finasteride tablets.
- Hair transplantation using FUT and FUE methods.
- Nutritional supplements: Your physician might also suggest some hair supplements that can help arrest hair fall. Dietary supplements containing Vitamin A, C, and Biotin, zinc, and iron can also help control hair fall caused because of genetics.
Treatment option for Chemotherapy induced Alopecia?
Alopecia post chemotherapy is a very common consequence of cancer treatments and therapies and it is often the most psychologically and socially devastating side effect. Many patients shy away from the treatments because of fear of hair fall and hair loss. However, in most cases, such alopecia is reversible but the recovery takes several months and even up to a year. Some basic latest treatment methods will speed up the healing:
- Scalp Cooling: This is a FDA approved method for patients suffering from breast cancer. Scalp cooling or hypothermia results in constriction of the blood vessels in the scalp, which in turn leads to reduced delivery of chemotherapy to the hair. Scalp cooling devices consist of cooling unit that circulate the coolant on the scalp. This is done about 30 minutes before the start of chemotherapy. Patients can feel some mild discomfort, nausea, and dry skin because of scalp cooling.
- Topical Minoxidil: Minoxidil helps by increasing the blood flow to the hair follicle thereby preventing miniaturization of hair follicle.
- QR678® hair regrowth treatment: QR678® is a FDA approved, completely safe hair regrowth treatment that has no side effects or causes any discomfort to the patient. Clinical trials have proved QR678 to be effective in treatment of chemotherapy induced alopecia in both men and women. The results of QR678® last lifelong.