Alopecia Areata

Alopecia Areata

Treatment

Hair is an enunciated and most sought out facial feature, and the way it is presented tends establish the concept of itself and the person’s personality. In hair loss, the ability to control and enhance attractiveness can get ambiguous and out of control. Interestingly, women’s self-esteem is much more dependent on physical appearance than men, and hair has a major impact on whether a person is aesthetically attractive or not.

WHAT IS ALOPECIA AREATA?

Alopecia areata (AA) is an inflammatory disease, characterized by chronic, recurrent, and deteriorating patchy hair loss. The condition may be limited to one or two small, rounded or oval, and bald spots that are well-circumscribed on the scalp or body (alopecia areata focal; AAF) or include the entire scalp (Alopecia areata totalis; AAT) or the whole body (Alopecia areata universalis; AAU). AA comprised between 1% and 2% of the population. AA may occur at any age; however, than 60% of cases are noticed before the age of 20 years. The incidence increases between the 2nd and 4th decades of life. The median age is 33 years. Around 14%–25% of patients are predicted to have ultimate total alopecia on the scalp. There is evidence that T cell lymphocytes aggregate around such hair follicle, trigger inflammation, and eventually lead to hair loss. Unfavourable stimulus like immunological and endocrine abnormalities, infections, and neurological/psychological disorders is believed to interfere with genetic cause to induce the disease. The scalp is the most commonly affected area. Particularly, the occipital area with 38.4% of males and 33.4% of females.

The classic clinical expression of AA is shedding of telogen hairs asymptomatically with patchy nonscarring hair loss. In addition to these findings, the hair shows accumulation of melanin pigment in the distal area of the body. Apart from these findings, patients of AA may have a debilitating effect on quality of life (QoL). The psychosocial consequences include stress, low self-esteem, a distorted self-image, and less active and satisfying social participation.

CURRENTLY AVAILABLE PRODUCTS

Nonsurgical treatment options of male androgenetic alopecia are limited. Currently, intralesional injection of triamcinolone, minoxidil 5% solution, topical or systemic corticosteroid, topical immunotherapy, psoralen photochemotherapy, or combination therapy are used to treat AA. However, each of these options may have side effects like skin atrophy, hypopigmentation, dermatitis, headache, increase in body hair with minoxidil use, loss of libido with the use of finasteride and high rate of relapse. Although these treatments are currently available and are widely used, there is still no safe and successful treatment for hair regrowth that will provide long term results.

QR678 NEO

QR678 Neo® formula is a plant-based polypeptide formulation that biologically reproduces the function of QR678® and they have been proved to be equivalent in the efficacy and safety. QR678Neo® contains a unique concentration of Sh-Polypeptide-9 (bio-mimicking Vascular endothelial growth factor -VEGF), Sh-Polypeptide-1 (bio-mimicking Fibroblast growth factor-bFGF), Sh-Oligopeptide-2 (bio-mimicking Insulin like growth factor–IGF 1), Sh-Polypeptide-3 (bio-mimicking Keratinocyte growth factor-KGF), copper tripeptide, and ShOligopeptide-4 (bio-mimicking Thymosin β4) dissolved in a sterile solution. QR678 Neo® has been shown to be successful as a hair regrowth therapy in male and female pattern hair loss, in female patients with alopecia in PCOS in terms of lessening hair loss and new hair growth considerably. Also in chemotherapy related alopecia, QR678 Neo® has proved its effectiveness in both men and women with record of lung and breast cancer. It has also shown remarkable effectiveness in combination with Minoxidil and Finasteride. The literature also suggests its beneficial effects and longevity of hair greater than PRP.

QR678 Neo® has proved to have a significant effect on new hair growth as it contains several growth factors that have been shown to have an anti-inflammatory effect with no side effects even over longer period. Polypeptide growth factors play an imperative role in restoring tissue injury, controlling cell replication, development and differentiation, enhancing wound healing, and tissue regeneration.

VEGF induces both vasculogenesis and angiogenesis following cellular damage. It has an immense impact on the permeability of blood vessels and is a potent angiogenic protein in a range of pathological neo-vascularization process. IGF-I and KGF cDNA gene transfer separately helps in the advancement of dermal and epidermal transformation. FGF was also found to be an important factor in healing. Also, vitamins present in QR678 Neo® have been verified to have anti-inflammatory property. Since all previously mentioned therapies have limited results with adverse effects on long-term follow-up and considerably high relapse rate, QR678 Neo® proves to be the most effective method devoid of any significant adverse effects.

CONCLUSION

Treatment options like immune-modulators, low-level laser/light, photo chemotherapy (psoralen plus ultraviolet A), sulfasalazine, and other have been evaluated and have been shown varied results for AA. Given the shortcomings of existing methods, it is the need of an hour to research on new treatment modalities with a purpose of enhancing results although reducing side effects. QR678 Neo® is a hair growth factor formulation which has anti-inflammatory effect. The bioengineered formulation of QR678 proved to be more beneficial for Male androgenetic alopecia (Male pattern hair loss) compared to PRP. The unique combination of growth factors is not only safe and efficacious but the patient is comfortable during and after the procedure warranting this product as one of a kind.

25 year old female , suffering from progressive alopecia areata since 1 year.She is also hypothyroid.

Treated with oral steroid pulse therapy ( saturday and sunday only), for few months and on oral immunosuppressant azathioprine daily for a few months.Topical minoxidil 5%, topical tacrolimus and hair supplements also given.
Response was very slow with the above, and QR678 was added after about 3 months of starting oral steroids and the results are impressive.

Finished 12 sessions of QR678 till date and is currently on once in 3 months QR678 session, and is completely off steroids and immunosuppressants. Continuing only on topical minoxidil and 3 monthly QR678 sessions.

NATURAL INGREDIENTS
BACKED BY SCIENCE

The QR678 therapy arrests hair fall & increases the thickness, number and density of existing hair follicles leading to greater coverage in hair loss. The polypeptides used in the formulation are present in our scalp, making it natural growth factor-based treatment. The polypeptides penetrate deep into the scalp and provide nourishment to the scalp, which results in hair growth.

Unlike other treatments that contain minoxidil & finasteride, QR678 therapy is completely devoid of side effects. QR678 received FDA approval for manufacturing and sale by being the most effective therapy for hair regrowth.

HOW DOES IT WORK?